Sildenafil is a medication used to treat erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). It works by increasing blood flow to the penis, which helps achieve and maintain an erection during sexual activity. For PAH, it helps to relax blood vessels in the lungs, improving exercise capacity and reducing symptoms.
Brand Names:
Viagra
Forms:
Tablets
Dosage: For erectile dysfunction, the usual starting dose is 50 mg, taken as needed about one hour before sexual activity. The dose can be adjusted based on effectiveness and tolerability, with a maximum recommended dose of 100 mg. For pulmonary arterial hypertension, the typical dose is 20 mg taken three times a day.
Composition:
Sildenafil ( 50 mg, 100 mg)
Mechanism of Action: Sildenafil works by inhibiting the enzyme phosphodiesterase type 5 (PDE5). This leads to an increase in cyclic GMP (cGMP), which relaxes the smooth muscles and dilates blood vessels in the penis, improving blood flow and allowing for an erection in response to sexual stimulation.
){kind=link}